Skip to Main content Skip to Navigation
Journal articles

Association of Corneal Hysteresis With Lamina Cribrosa Curvature in Primary Open Angle Glaucoma

Abstract : PURPOSE. To investigate whether corneal biomechanical properties are associated with the lamina cribrosa (LC) curvature in eyes with primary open angle glaucoma (POAG). METHODS. Corneal biomechanical properties and LC curvature were assessed in 65 treatmentnaïve POAG patients. Corneal biomechanical properties, including corneal hysteresis (CH), corneal resistance factor (CRF), and corneal-compensated intraocular pressure (IOPcc), were measured using an ocular response analyzer (ORA; Reichert Ophthalmic Instruments). LC curvature was assessed by measuring the LC curvature index (LCCI) on B-scan images obtained using spectral-domain optical coherence tomography (OCT). The LCCI was determined by measuring LC curve depth on the anterior LC surface and the width of the reference line. RESULTS. The LCCI was correlated with CH (P ¼ 0.001), CRF (P ¼ 0.012) and IOPcc (P ¼ 0.001) in the univariate analysis. To adjust multicollinearity, principal component analysis was performed, and multivariate regression analyses were conducted using one variable from each component. The larger LCCI was associated with larger IOPcc (P < 0.001), smaller CRF (P ¼ 0.001) and smaller CH (P < 0.001). CONCLUSIONS. Lower CH was associated with a more posteriorly curved LC in treatment naïve POAG patients. This finding may provide a basic explanation for the reported association between CH and an increased risk for glaucoma development and progression, and support a potential value of CH for risk assessment for glaucoma.
Document type :
Journal articles
Complete list of metadata

https://hal-upf.archives-ouvertes.fr/hal-03180234
Contributor : Elodie Delcambre-Maillard Connect in order to contact the contributor
Submitted on : Wednesday, March 24, 2021 - 6:58:43 PM
Last modification on : Tuesday, August 10, 2021 - 3:12:04 PM

File

Association of Corneal Hystere...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

UPF

Citation

Kyoung Min Lee, Tae-Woo Kim, Eun Ji Lee, Michaël Girard, Jean-Martial Mari, et al.. Association of Corneal Hysteresis With Lamina Cribrosa Curvature in Primary Open Angle Glaucoma. Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2019, Vol. 60 (n°13), pp. 4171-4177. ⟨10.1167/iovs.19-27087⟩. ⟨hal-03180234⟩

Share

Metrics

Record views

12

Files downloads

25